Skip to main content
Log in

Bigger, faster, better? Rhetorics and practices of large-scale research in contemporary bioscience

  • Introduction
  • Published:
BioSocieties Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Notes

  1. As the commentary by Lezaun points out, there is a double act of value creation and destruction in these collaborative practices. Devaluation is an equally significant process if researchers are to be encouraged to share resources previously held by individual laboratories or institutions.

  2. For a critical discussion and review of the concept of scale in geography see Marston et al (2005), Leitner and Miller (2007), and Moore (2008). The relations between scale, size and different orders of complexity have also been a focus of work in STS; see, for example, Law (2004) and Kwa (2002). A recent interdisciplinary workshop on Scalography in 2009 bought together scholars in STS, geography and other disciplines to explore the potential of turning the problem of scale into a object of productive enquiry. See http://www.sbs.ox.ac.uk/research/sts/research/Pages/scalography.aspx, accessed 21 August 2013.

  3. There are now a large number of global and regional studies of science and innovation outside of Europe and the United States, most notably in China, India and Brazil (see, for example, Sunder Rajan, 2006; Salter et al, 2009). These explore the situated nature of knowledge production in modern value knowledge networks that are increasingly globalised, even while distribution of therapeutic and other benefits of the biosciences remains uneven.

  4. We are not in a position to address potential parallels between contemporary developments in biology and physics, owing to the relatively scarce literature available on large-scale physics today. Forthcoming publications by Sharon Traweek and collaborators will undoubtedly facilitate comparison.

  5. There is also growing demand for databases capable of integrating research across diverse research areas, focusing on different organisms, levels of organisation and types of data.

  6. Philosophers of biology have reflected extensively on what it means for biological claims to be aggregated, and how one can think about unification and ‘theory’ in biology (see, for example, the Biological Theory special issue on ‘The Meaning of Theory in Biology’ edited by Pigliucci et al (2013)).

  7. There are growing concerns about who might be left ‘outside’ of these research projects and thus be in a position to review them from what scientists would deem an objective position (Xin and Yidong, 2006).

References

  • Anderson, W. (2009) From subjugated knowledge to conjugated subjects: Science and globalisation, or postcolonial studies of science? Postcolonial Studies 12 (4): 389–400.

    Article  Google Scholar 

  • Aronova, E., Baker, K. and Oreskes, N. (2010) Big science and big data in biology: From the International Geophysical Year through the International Biological Program to the Long Term Ecological Research (LTER) network, 1957–present. Historical Studies in the Natural Sciences 40 (2): 183–224.

    Article  Google Scholar 

  • Balmer, B. (1996) Managing mapping in the Human Genome Project. Social Studies of Science 26 (3): 531–573.

    Article  Google Scholar 

  • Bonneuil, C. and Thomas, F. (2009) Gènes, pouvoirs et profits. Recherche publique et régimes de production des savoirs de Mendel aux OGM. Paris, France: Quae.

    Google Scholar 

  • Bulkeley, H. (2005) Reconfiguring environmental governance: Towards a politics of scales and networks. Political Geography 24 (8): 875–902.

    Article  Google Scholar 

  • Calvert, J. and Martin, P. (2009) The role of social scientists in synthetic biology. EMBO Reports 10 (3): 201–204.

    Article  Google Scholar 

  • Cassidy, A. and Woods, A. (2012) Tracing the histories of one health: Human/animal disease and disciplinarity. Paper presented at the Global Risk Forum One Health Summit; 19–21 February, Davos, Switzerland.

  • Collins, F.S., Morgan, M. and Patrinos, A. (2003) The Human Genome Project: Lessons from large-scale biology. Science 300 (5617): 286–290.

    Article  Google Scholar 

  • Davies, G. (2012) What is a humanized mouse? Remaking the species and spaces of translational medicine. Body & Society 18 (3–4): 126–155.

    Article  Google Scholar 

  • Doubleday, R. (2007) Organizing accountability: Co-production of technoscientific and social worlds in a nanoscience laboratory. Area 39 (2): 166–175.

    Article  Google Scholar 

  • Dupré, J. (2012) Processes of Life: Essays in the Philosophy of Biology. Oxford: Oxford University Press.

    Book  Google Scholar 

  • Esparza, J. and Yamada, T. (2007) The discovery value of ‘big science’. Journal of Experimental Medicine 204 (4): 701–704.

    Article  Google Scholar 

  • Galison, P. (1997) Image and Logic: A Material Culture of Microphysics. Chicago, IL: University of Chicago Press.

    Google Scholar 

  • Gaudillière, J.P. and Löwy, I. (eds.) (1998) The Invisible Industrialist: Manufactures and the Production of Scientific Knowledge. London: Palgrave Macmillan.

    Book  Google Scholar 

  • Harding, S. (2011) The Postcolonial Science and Technology Studies Reader. Durham, NC: Duke University Press.

    Book  Google Scholar 

  • Howlett, P. and Morgan, M.S. (eds.) (2010) How Well do Facts Travel? The Dissemination of Reliable Knowledge. Cambridge, UK: Cambridge University Press.

    Book  Google Scholar 

  • Hughes, J. (2002) The Manhattan Project: Big Science and the Atom Bomb. New York: Columbia University Press.

    Google Scholar 

  • Hulme, M. (2010) Problems with making and governing global kinds of knowledge. Global Environmental Change 20 (4): 558–564.

    Article  Google Scholar 

  • Kevles, D. (1997) Big science and big politics in the United States: Reflections on the death of the SSC and the life of the Human Genome Project. Historical Studies in the Physical and Biological Sciences 27 (2): 269–297.

    Article  Google Scholar 

  • Knorr-Cetina, K.D. (1999) Epistemic Cultures: How the Sciences Make Knowledge. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Kriege, J. (1996) History of CERN, Volume III. The Years of Consolidation 1966–1980. Amsterdam, the Netherlands: North Holland Publishers.

    Google Scholar 

  • Kwa, C. (2002) Romantic and baroque conceptions of complex wholes in the sciences. In: J. Law and A.-M. Mol (eds.) Complexities: Social Studies of Knowledge. Durham, NC: Duke University Press, pp. 23–52.

    Chapter  Google Scholar 

  • Landecker, H. (2013) Post-industrial metabolism. Public Culture 25 (3).

  • Latour, B. (1987) Science in Action. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Law, J. (2004) And if the global were small and noncoherent? Method, complexity and the baroque. Environment and Planning D: Society and Space 22 (1): 13–26.

    Article  Google Scholar 

  • Leitner, H. and Miller, B. (2007) Scale and the limitations of ontological debate: A commentary on Martson, Jones and Woodward. Transactions of the Institute of British Geographers 32 (1): 116–125.

    Article  Google Scholar 

  • Leonelli, S. (2010a) The commodification of knowledge exchange: Governing the circulation of biological data. In: H. Radder (ed.) The Commodification of Academic Research: Science and the Modern University. Pittsburgh, PA: Pittsburgh University Press.

    Google Scholar 

  • Leonelli, S. (2010b) Documenting the emergence of bio-ontologies: Or, why researching bioinformatics requires HPSSB. History and Philosophy of the Life Sciences 32 (1): 105–126.

    Google Scholar 

  • Leonelli, S. and Ankeny, R.A. (2012) Re-thinking organisms: The impact of databases on model organism biology. Studies in the History and the Philosophy of the Biological and Biomedical Sciences 43 (1): 29–36.

    Article  Google Scholar 

  • Livingstone, D. (1995) The spaces of knowledge: Contributions towards a historical geography of science. Environment and Planning D: Society and Space 13 (1): 5–34.

    Article  Google Scholar 

  • Livingstone, D. (2003) Putting Science in its Place: Geographies of Scientific Knowledge. Chicago, IL: University of Chicago Press.

    Book  Google Scholar 

  • Marston, S., Jones, J.P. and Woodward, K. (2005) Human geography without scale. Transactions of the Institute of British Geographers 30 (4): 416–432.

    Article  Google Scholar 

  • Moore, A. (2008) Rethinking scale as a geographical category: From analysis to practice. Progress in Human Geography 32 (2): 203–225.

    Article  Google Scholar 

  • Mueller-Wille, S. (2004) Walnuts at Hudson bay, coral reefs in Gotland: The colonialism of Linnaean botany. In: L. Schiebinger and C. Swan (eds.) Colonial Botany. Philadelphia, PA: University of Pennsylvania Press, pp. 34–48.

    Google Scholar 

  • Nass, S.J. and Stillman, B.W. (eds.) (2003) Large-Scale Biomedical Science: Exploring Strategies for Future Research. Washington DC: The National Academies Press, p. 280.

    Book  Google Scholar 

  • Naylor, S. (2005) Historical geography: Knowledge, in place and on the move. Progress in Human Geography 29 (5): 626–634.

    Article  Google Scholar 

  • O’Malley, M.A. and Dupré, J. (2005) Fundamental issues in systems biology. BioEssays 27 (12): 1270–1276.

    Article  Google Scholar 

  • O’Malley, M.A. and Stotz, K. (2011) Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches. Philosophy, Ethics and Humanities in Medicine 6: article 2.

    Article  Google Scholar 

  • Parker, J.N., Vermeulen, N. and Penders, B. (eds.) (2010) Collaboration in the New Life Sciences. Aldershot, UK: Ashgate.

    Google Scholar 

  • Parry, B. (2004) Trading the Genome: Investigating the Commodification of Bio-Information. New York: Columbia University Press.

    Book  Google Scholar 

  • Pigliucci, M., Sterelny, K. and Callebaut, W. (2013) The meaning of ‘Theory’ in biology. Biological Theory 7 (4): 285–286.

    Article  Google Scholar 

  • Powell, R. (2007) Geographies of science: Histories, localities, practices, futures. Progress in Human Geography 31 (3): 309–329.

    Article  Google Scholar 

  • Salter, B., Gottweis, H. and Waldby, C. (2009) The Global Politics of Human Embryonic Stem Cell Science: Regenerative Medicine in Transition. Basingstoke, UK: Palgrave Macmillan.

    Google Scholar 

  • Schaffer, S. (1998) Physics laboratories and the Victorian country house. In: C. Smith, J. Agar and G. Schmidt (eds.) Making Space for Science: Territorial Themes in the Shaping of Knowledge. Basingstoke, UK: Palgrave Macmillan, pp. 149–180.

    Chapter  Google Scholar 

  • Secord, J. (2004) Knowledge in transit. Isis 95 (4): 654–672.

    Article  Google Scholar 

  • Sunder Rajan, K. (2006) Biocapital: The Constitution of Postgenomic Life. London: Duke University Press.

    Book  Google Scholar 

  • Sunder Rajan, K. and Leonelli, S. (2013) Biomedical trans-actions, postgenomics, and knowledge/value. Public Culture 25 (3 71): 463–475.

    Article  Google Scholar 

  • Traweek, S. (1988) Beams and Lifetimes: The World of High Energy Physicists. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Vermeulen, N. (2010) Supersizing Science: On Building Large-Scale Research Projects in Biology. Boca Raton, FL: Dissertation.com.

    Google Scholar 

  • Weinberg, A. (1999) The birth of big biology. Nature 401 (6755): 738.

    Article  Google Scholar 

  • Weinberg, A.M. (1967) Reflections on Big Science. Cambridge, MA: MIT Press.

    Google Scholar 

  • Xin, H. and Yidong, G. (2006) China bets big on big science. Science 3011 (5767): 1548–1549.

    Article  Google Scholar 

Download references

Acknowledgements

The assembled papers have been developed, discussed and refined in response to the workshop ‘Making it Big? Tracing collaboration, complexity and control in the biosciences’ held in Exeter on 17–18 March 2011, organised by the guest editors of this special issue (Davies, Frow and Leonelli) and funded by the Economic and Social Research Council (ESRC). We would like to acknowledge the assistance of the ESRC Genomics Policy and Research Forum, Egenis and the University of Exeter in facilitating this workshop, and offer our thanks to all workshop participants for their contributions, with particular thanks to Kaushik Sunder Rajan and Javier Lezaun for their commentaries on the event.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davies, G., Frow, E. & Leonelli, S. Bigger, faster, better? Rhetorics and practices of large-scale research in contemporary bioscience. BioSocieties 8, 386–396 (2013). https://doi.org/10.1057/biosoc.2013.26

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1057/biosoc.2013.26

Navigation